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Aspirin Sinus relief medications Acetaminophen (Tylenol) Non-steroidal anti-inflammatory medications (such as Aleve) Sedatives for sleep Codeine and prescription narcotics Over-the-counter combination headache remedies containing caffeine (including Anacin, Excedrin, Bayer Select) Ergotamine preparations (for example Cafergot, Migergot, Ergomar, Bellergal-S, Bel-Phen-Ergot S, Phenerbel-S, Ercaf, Wigraine, and Cafatine PB) Butalbital combination anesthetics (Goody's Headache Powder, Supac, fiorinal, fioricet) The CR report took a really close look with a group of medicine called the triptans, which have become the normally prescribed drug for migraine patients, despite the idea that MDs are unclear as to how they work (it's believed they affect how a nervous system handles serotonin, which is involved in pain processing). It is most effective when taken once the migraine starts. The main medications which are useful for headache treatment are beta blockers like Tenormin and Lopressor. 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